Evolution of longevity improves immunity in Drosophila

D. K. Fabian; K. Garschall; P. Klepsatel; G. Santos-Matos; E. Sucena et al.

Evolution Letters. 2018-12-01.

DOI : 10.1002/evl3.89.


Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

I. Iatsenko; J.-P. Boquete; B. Lemaitre

Immunity. 2018-11-20.

DOI : 10.1016/j.immuni.2018.09.017.


Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

I. Miguel-Aliaga; H. Jasper; B. Lemaitre

Genetics. 2018-10-01.

DOI : 10.1534/genetics.118.300224.


The melanization reaction in Drosophila: More than black or white

J. P. Dudzic / B. Lemaitre (Dir.)

Lausanne, EPFL, 2018.

DOI : 10.5075/epfl-thesis-8934.


An IMD-like pathway mediates both endosymbiont control and host immunity in the cereal weevil Sitophilus spp.

J. Maire; C. Vincent-Monegat; F. Masson; A. Zaidman-Remy; A. Heddi


DOI : 10.1186/s40168-017-0397-9.


Male-killing toxin in a bacterial symbiont of Drosophila

T. Harumoto; B. Lemaitre

Nature. 2018.

DOI : 10.1038/s41586-018-0086-2.


In Vitro Culture of the Insect Endosymbiont Spiroplasma poulsonii Highlights Bacterial Genes Involved in Host-Symbiont Interaction

F. Masson; S. Calderon Copete; F. Schüpfer; G. Garcia-Arraez; B. Lemaitre et al.

mBio. 2018.

DOI : 10.1128/mBio.00024-18.


Common and unique strategies of male killing evolved in two distinct Drosophila symbionts

T. Harumoto; T. Fukatsu; B. Lemaitre

Proceedings of the Royal Society B: Biological Sciences. 2018.

DOI : 10.1098/rspb.2017.2167.


The double-edged toxins

M. G. Garcia Arraez / B. Lemaitre (Dir.)

Lausanne, EPFL, 2018.

DOI : 10.5075/epfl-thesis-8782.



Transforming Growth Factor beta/Activin signaling in neurons increases susceptibility to starvation

W.-B. A. Chng; R. Koch; X. Li; S. Kondo; E. Nagoshi et al.

Plos One. 2017.

DOI : 10.1371/journal.pone.0187054.


The gram-negative sensing receptor PGRP-LC contributes to grooming induction in Drosophila

A. Yanagawa; C. Neyen; B. Lemaitre; F. Marion-Poll

Plos One. 2017.

DOI : 10.1371/journal.pone.0185370.


Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

A. Dostalova; S. Rommelaere; M. Poidevin; B. Lemaitre

Bmc Biology. 2017.

DOI : 10.1186/s12915-017-0408-0.


A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila

Z. Zhai; J.-P. Boquete; B. Lemaitre

Plos Genetics. 2017.

DOI : 10.1371/journal.pgen.1006854.


Science, narcissism and the quest for visibility

B. Lemaitre

Febs Journal. 2017.

DOI : 10.1111/febs.14032.


Protection from within

F. Masson; B. Lemaitre

Elife. 2017.

DOI : 10.7554/eLife.24111.


Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

W.-B. A. Chng; V. Hietakangas; B. Lemaitre

Trends In Endocrinology And Metabolism. 2017.

DOI : 10.1016/j.tem.2016.11.003.



PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway

I. Iatsenko; S. Kondo; D. Mengin-Lecreulx; B. Lemaitre

Immunity. 2016.

DOI : 10.1016/j.immuni.2016.10.029.


Male-killing symbiont damages host's dosage-compensated sex chromosome to induce embryonic apoptosis

T. Harumoto; H. Anbutsu; B. Lemaitre; T. Fukatsu

Nature Communications. 2016.

DOI : 10.1038/ncomms12781.


The Drosophila gut response to infection

M. Bou Sleiman / B. Lemaitre; B. Deplancke (Dir.)

Lausanne, EPFL, 2016.

DOI : 10.5075/epfl-thesis-7151.


Connecting the obesity and the narcissism epidemics

B. Lemaitre

Medical Hypotheses. 2016.

DOI : 10.1016/j.mehy.2016.08.001.


The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

C. Neyen; C. Runchel; F. Schüpfer; P. Meier; B. Lemaitre

Nature Immunology. 2016.

DOI : 10.1038/ni.3536.


Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications That Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity

A. Espaillat; O. Forsmo; K. El Biari; R. Björk; B. Lemaitre et al.

Journal of the American Chemical Society. 2016.

DOI : 10.1021/jacs.6b04430.


The Role of Lipid Competition for Endosymbiont-Mediated Protection against Parasitoid Wasps in Drosophila

J. C. Paredes; J. K. Herren; F. Schüpfer; B. Lemaitre

mBio. 2016.

DOI : 10.1128/mBio.01006-16.


Cell Division by Longitudinal Scission in the Insect Endosymbiont

E. Ramond; C. Maclachlan; S. Clerc-Rosset; G. W. Knott; B. Lemaitre

mBio. 2016.

DOI : 10.1128/mBio.00881-16.


The dual oxidase gene BdDuox regulates the intestinal bacterial community homeostasis of Bactrocera dorsalis

Z. Yao; A. Wang; Y. Li; Z. Cai; B. Lemaitre et al.

Isme Journal. 2016.

DOI : 10.1038/ismej.2015.202.


Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

S. Chakrabarti; J. P. Dudzic; X. Li; E. J. Collas; J.-P. Boquete et al.

PLOS Genetics. 2016.

DOI : 10.1371/journal.pgen.1006089.


Sensing Gram-negative bacteria: a phylogenetic perspective

C. Neyen; B. Lemaitre

Current Opinion In Immunology. 2016.

DOI : 10.1016/j.coi.2015.10.007.



Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis

Z. Zhai; S. Kondo; N. Ha; J.-P. Boquete; M. Brunner et al.

Nature Communications. 2015.

DOI : 10.1038/ncomms10219.


Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association

P. T. Hamilton; J. Votypka; A. Dostalova; V. Yurchenko; N. H. Bird et al.

Mbio. 2015.

DOI : 10.1128/mBio.01356-15.


Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens

R. K. Vijendravarma; S. Narasimha; S. Chakrabarti; A. Babin; S. Kolly et al.

Ecology Letters. 2015.

DOI : 10.1111/ele.12490.


Drosophila innate immunity: regional and functional specialization of prophenoloxidases

J. P. Dudzic; S. Kondo; R. Ueda; C. M. Bergman; B. Lemaitre

BMC biology. 2015.

DOI : 10.1186/s12915-015-0193-6.


Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

W. B. Chng / B. Lemaitre (Dir.)

Lausanne, EPFL, 2015.

DOI : 10.5075/epfl-thesis-6755.


X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form

P. Leone; C. Bebeacua; O. Opota; C. Kellenberger; B. Klaholz et al.

Journal Of Biological Chemistry. 2015.

DOI : 10.1074/jbc.M115.646109.


From Embryo to Adult: Hematopoiesis along the Drosophila Life Cycle

E. Ramond; M. Meister; B. Lemaitre

Developmental Cell. 2015.

DOI : 10.1016/j.devcel.2015.05.002.


Genome Sequence of the Drosophila melanogaster Male-Killing Spiroplasma Strain MSRO Endosymbiont

J. C. Paredes; J. K. Herren; F. Schuepfer; R. Marin; S. Claverol et al.

Mbio. 2015.

DOI : 10.1128/mBio.02437-14.


Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

M. S. B. Sleiman; D. Osman; A. Massouras; A. A. Hoffmann; B. Lemaitre et al.

Nature Communications. 2015.

DOI : 10.1038/ncomms8829.


Different flavors of Toll guide olfaction

C. Neyen; B. Lemaitre

Trends In Immunology. 2015.

DOI : 10.1016/


Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties

I. Speciale; I. Paciello; L. L. Fazio; L. Sturiale; A. Palmigiano et al.

Carbohydrate Research. 2015.

DOI : 10.1016/j.carres.2015.04.017.


The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects

C. Neyen; O. Binggeli; P. Roversi; L. Bertin; M. B. Sleiman et al.

Developmental And Comparative Immunology. 2015.

DOI : 10.1016/j.dci.2014.12.011.


The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster

A. J. Bretscher; V. Honti; O. Binggeli; O. Burri; M. Poidevin et al.

Biology Open. 2015.

DOI : 10.1242/bio.201410595.



Pseudomonas entomophila: A Versatile Bacterium with Entomopathogenic Properties

G. Dieppois; O. Opota; J. Lalucat; B. Lemaitre

Pseudomonas; Dordrecht: Springer, 2014. p. 25-49.


Transforming Growth Factor beta/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

W.-B. A. Chng; M. S. B. Sleiman; F. Schuepfer; B. Lemaitre

Cell Reports. 2014.

DOI : 10.1016/j.celrep.2014.08.064.


The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine

S. Chakrabarti; M. Poidevin; B. Lemaitre

Plos Genetics. 2014.

DOI : 10.1371/journal.pgen.1004659.


Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila

O. Binggeli; C. Neyen; M. Poidevin; B. Lemaitre

Plos Pathogens. 2014.

DOI : 10.1371/journal.ppat.1004067.


The unsuspected complexity of the digestive tract of the fruitfly Towards a model of functional regionalization

D. Osman; N. Buchon

M S-Medecine Sciences. 2014.

DOI : 10.1051/medsci/20143005003.


Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

N. A. Broderick; N. Buchon; B. Lemaitre

Mbio. 2014.

DOI : 10.1128/mBio.01117-14.


Methods to study Drosophila immunity

C. Neyen; A. J. Bretscher; O. Binggeli; B. Lemaitre

Methods. 2014.

DOI : 10.1016/j.ymeth.2014.02.023.


Insect endosymbiont proliferation is limited by lipid availability

J. K. Herren; J. C. Paredes; F. Schuepfer; K. Arafah; P. Bulet et al.

Elife. 2014.

DOI : 10.7554/eLife.02964.


The useful gate-crasher

J. C. Paredes Escobar / B. Lemaitre (Dir.)

Lausanne, EPFL, 2014.

DOI : 10.5075/epfl-thesis-6309.


The Effectual Hitchhiker

J. K. Herren / B. Lemaître (Dir.)

Lausanne, EPFL, 2014.

DOI : 10.5075/epfl-thesis-6079.



The Digestive Tract of Drosophila melanogaster

B. Lemaitre; I. Miguel-Aliaga

Annual review of genetics. 2013.

DOI : 10.1146/annurev-genet-111212-133343.


Functional Analysis of PGRP-LA in Drosophila Immunity

M. Gendrin; A. Zaidman-Remy; N. A. Broderick; J. Paredes; M. Poidevin et al.

Plos One. 2013.

DOI : 10.1371/journal.pone.0069742.


Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila

M. Blemont; R. Vincentelli; C. Kellenberger; O. Opota; B. Lemaitre et al.

Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013.

DOI : 10.1107/S174430911301885X.


Gut homeostasis in a microbial world: insights from Drosophila melanogaster

N. Buchon; N. A. Broderick; B. Lemaitre

Nature Reviews Microbiology. 2013.

DOI : 10.1038/nrmicro3074.


Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila (vol 3, pg 1725, 2013)

N. Buchon; D. Osman; F. P. A. David; H. Y. Fang; J.-P. Boquete et al.

Cell Reports. 2013.

DOI : 10.1016/j.celrep.2013.05.019.


Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

N. Buchon; D. Osman; F. P. A. David; H. Y. Fang; J.-P. Boquete et al.

Cell Reports. 2013.

DOI : 10.1016/j.celrep.2013.04.001.


Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens

B. Lemaitre; S. E. Girardin

Nature Reviews Microbiology. 2013.

DOI : 10.1038/nrmicro3029.


Role and regulation of the melanization reaction in Drosophila immune response

O. Binggeli / B. Lemaitre (Dir.)

Lausanne, EPFL, 2013.

DOI : 10.5075/epfl-thesis-5840.


The contribution of the host stress response to the pathogenesis of Pseudomonas entomophila in the Drosophila intestine

S. Chakrabarti / B. Lemaitre (Dir.)

Lausanne, EPFL, 2013.

DOI : 10.5075/epfl-thesis-5794.


Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery

J. K. Herren; J. C. Paredes; F. Schüpfer; B. Lemaitre

mBio. 2013.

DOI : 10.1128/mBio.00532-12.


dRYBP Contributes to the Negative Regulation of the Drosophila Imd Pathway

R. Aparicio; C. Neyen; B. Lemaitre; A. Busturia

PloS one. 2013.

DOI : 10.1371/journal.pone.0062052.



The drosophila gut: A new paradigm for epithelial immune response

B. Lemaitre

2012. 10th Joint Meeting of the International-Cytokine-Society (ICS) / Meeting of the International-Society-for-Interferon-and-Cytokine-Research (ISICR) , Geneva, SWITZERLAND , SEP 11-14, 2012. p. 494-494.

DOI : 10.1016/j.cyto.2012.06.305.


Distinguishing dead from alive - a novel intracellular receptor mediates ligand-specific regulation of Relish-dependent immune activation in Drosophila

C. Neyen; B. Lemaitre

2012. European Congress of Immunology , Glasgow, SCOTLAND , SEP 05-08, 2012. p. 32-32.


Gut-associated microbes of Drosophila melanogaster

N. A. Broderick; B. Lemaitre

Gut microbes. 2012.

DOI : 10.4161/gmic.19896.


Insect-microbe interactions: the good, the bad and the others

J. Herren; B. Lemaitre

Current opinion in microbiology. 2012.

DOI : 10.1016/j.mib.2012.05.014.


Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE

C. Neyen; M. Poidevin; A. Roussel; B. Lemaitre

Journal of immunology (Baltimore, Md. : 1950). 2012.

DOI : 10.4049/jimmunol.1201022.


Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut

S. Chakrabarti; P. Liehl; N. Buchon; B. Lemaitre

Cell host & microbe. 2012.

DOI : 10.1016/j.chom.2012.06.001.


Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division

D. Osman; N. Buchon; S. Chakrabarti; Y.-T. Huang; W.-C. Su et al.

Journal of cell science. 2012.

DOI : 10.1242/jcs.113100.


Taxonomic characterisation of Pseudomonas strain L48 and formal proposal of Pseudomonas entomophila sp nov.

M. Mulet; M. Gomila; B. Lemaitre; J. Lalucat; E. Garcia-Valdes

Systematic And Applied Microbiology. 2012.

DOI : 10.1016/j.syapm.2011.12.003.



Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function

A. Zaidman-Rémy; M. Poidevin; M. Hervé; D. P. Welchman; J. C. Paredes et al.

PloS one. 2011.

DOI : 10.1371/journal.pone.0017231.


Negative Regulation by Amidase PGRPs Shapes the Drosophila Antibacterial Response and Protects the Fly from Innocuous Infection

J. C. Paredes; D. P. Welchman; M. Poidevin; B. Lemaitre

Immunity. 2011.

DOI : 10.1016/j.immuni.2011.09.018.


Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

T. Kuraishi; O. Binggeli; O. Opota; N. Buchon; B. Lemaitre

Proceedings of the National Academy of Sciences of the United States of America. 2011.

DOI : 10.1073/pnas.1105994108.


Spiroplasma and host immunity: activation of humoral immune responses increases endosymbiont load and susceptibility to certain Gram-negative bacterial pathogens in Drosophila melanogaster

J. K. Herren; B. Lemaitre

Cellular microbiology. 2011.

DOI : 10.1111/j.1462-5822.2011.01627.x.


Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

O. Opota; I. Vallet-Gély; R. Vincentelli; C. Kellenberger; I. Iacovache et al.

PLoS pathogens. 2011.

DOI : 10.1371/journal.ppat.1002259.


Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

J.-R. Alattia; T. Kuraishi; M. Dimitrov; I. Chang; B. Lemaitre et al.

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011.

DOI : 10.1096/fj.10-174078.



Toll-like receptors - an evolutionary perspective

B. Lemaitre

2010. Annual Congress of the British-Society-for-Immunology , Liverpool, ENGLAND , Dec 06-10, 2010. p. 19-19.


Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

N. Buchon; N. A. Broderick; T. Kuraishi; B. Lemaitre

BMC biology. 2010.

DOI : 10.1186/1741-7007-8-152.


Association of hemolytic activity of Pseudomonas entomophila, a versatile soil bacterium, with cyclic lipopeptide production

I. Vallet-Gely; A. Novikov; L. Augusto; P. Liehl; G. Bolbach et al.

Applied and environmental microbiology. 2010.

DOI : 10.1128/AEM.02112-09.


A secondary metabolite acting as a signalling molecule controls Pseudomonas entomophila virulence

I. Vallet-Gely; O. Opota; A. Boniface; A. Novikov; B. Lemaitre

Cellular microbiology. 2010.

DOI : 10.1111/j.1462-5822.2010.01501.x.



Recognition and response to microbial infection in Drosophila

N. A. Broderick; B. Lemaitre

Insect Infection and Immunity: Evolution, Ecology, and Mechanisms; Oxford: Oxford University Press, 2009. p. 13-33.


Insect immunity: from pattern recognition to symbiont-mediated host defense

D. P. Welchman; S. Aksoy; F. Jiggins; B. Lemaitre

Cell host & microbe. 2009.

DOI : 10.1016/j.chom.2009.07.008.


Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection

A. Defaye; I. Evans; M. Crozatier; W. Wood; B. Lemaitre et al.

Journal of innate immunity. 2009.

DOI : 10.1159/000210264.


Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation

N. Buchon; N. A. Broderick; M. Poidevin; S. Pradervand; B. Lemaitre

Cell host & microbe. 2009.

DOI : 10.1016/j.chom.2009.01.003.


Proteolytic cascade for the activation of the insect toll pathway induced by the fungal cell wall component

K.-B. Roh; C.-H. Kim; H. Lee; H.-M. Kwon; J.-W. Park et al.

The Journal of biological chemistry. 2009.

DOI : 10.1074/jbc.M109.007419.


A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

N. Buchon; M. Poidevin; H.-M. Kwon; A. Guillou; V. Sottas et al.

Proceedings of the National Academy of Sciences of the United States of America. 2009.

DOI : 10.1073/pnas.0901924106.


Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

N. Buchon; N. A. Broderick; S. Chakrabarti; B. Lemaitre

Genes & development. 2009.

DOI : 10.1101/gad.1827009.


A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK

P. Geuking; R. Narasimamurthy; B. Lemaitre; K. Basler; F. Leulier

PloS one. 2009.

DOI : 10.1371/journal.pone.0007709.


Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila

M. Gendrin; D. P. Welchman; M. Poidevin; M. Hervé; B. Lemaitre

PLoS pathogens. 2009.

DOI : 10.1371/journal.ppat.1000694.



Cyanogenesis in Pseudomonas entomophila: an entomopathogenic bacterium

B. Ryall; H. Nasser; B. Lemaitre; D. Mossialos; H. D. Williams

2008. Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference , Athens, GREECE , Jun 28-Jul 03, 2008. p. 289-289.


Toll-like receptors--taking an evolutionary approach

F. Leulier; B. Lemaitre

Nature reviews. Genetics. 2008.

DOI : 10.1038/nrg2303.


Bacterial strategies to overcome insect defences

I. Vallet-Gely; B. Lemaitre; F. Boccard

Nature reviews. Microbiology. 2008.

DOI : 10.1038/nrmicro1870.


Drosophila immunity: methods for monitoring the activity of Toll and Imd signaling pathways

Y. Romeo; B. Lemaitre

Methods in molecular biology (Clifton, N.J.). 2008.

DOI : 10.1007/978-1-59745-570-1_22.


Animal models for host-pathogen interactions

B. Lemaitre; F. M. Ausubel

Current opinion in microbiology. 2008.

DOI : 10.1016/j.mib.2008.05.002.


PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling

N. Lhocine; P. S. Ribeiro; N. Buchon; A. Wepf; R. Wilson et al.

Cell host & microbe. 2008.

DOI : 10.1016/j.chom.2008.07.004.


Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation

C. Scherfer; H. Tang; Z. Kambris; N. Lhocine; C. Hashimoto et al.

Developmental biology. 2008.

DOI : 10.1016/j.ydbio.2008.08.030.


A serpin that regulates immune melanization in the respiratory system of Drosophila

H. Tang; Z. Kambris; B. Lemaitre; C. Hashimoto

Developmental cell. 2008.

DOI : 10.1016/j.devcel.2008.08.017.


Evf, a virulence factor produced by the Drosophila pathogen Erwinia carotovora, is an S-palmitoylated protein with a new fold that binds to lipid vesicles

S. Quevillon-Cheruel; N. Leulliot; C. A. Muniz; M. Vincent; J. Gallay et al.

The Journal of biological chemistry. 2008.

DOI : 10.1074/jbc.M808334200.



The host defense of Drosophila melanogaster

B. Lemaitre; J. Hoffmann

Annual review of immunology. 2007.

DOI : 10.1146/annurev.immunol.25.022106.141615.



Insect immunity: the post-genomic era

J. Bangham; F. Jiggins; B. Lemaitre

Immunity. 2006.

DOI : 10.1016/j.immuni.2006.07.002.


A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity

I.-H. Jang; N. Chosa; S.-H. Kim; H.-J. Nam; B. Lemaitre et al.

Developmental cell. 2006.

DOI : 10.1016/j.devcel.2005.11.013.


The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila

S. Brun; S. Vidal; P. Spellman; K. Takahashi; H. Tricoire et al.

Genes to cells : devoted to molecular & cellular mechanisms. 2006.

DOI : 10.1111/j.1365-2443.2006.00953.x.


The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection

A. Zaidman-Rémy; M. Hervé; M. Poidevin; S. Pili-Floury; M.-S. Kim et al.

Immunity. 2006.

DOI : 10.1016/j.immuni.2006.02.012.


Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation

Z. Kambris; S. Brun; I.-H. Jang; H.-J. Nam; Y. Romeo et al.

Current biology : CB. 2006.

DOI : 10.1016/j.cub.2006.03.020.


The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation

C. Scherfer; M. R. Qazi; K. Takahashi; R. Ueda; M. S. Dushay et al.

Developmental biology. 2006.

DOI : 10.1016/j.ydbio.2006.03.019.


Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila

N. Vodovar; D. Vallenet; S. Cruveiller; Z. Rouy; V. Barbe et al.

Nature biotechnology. 2006.

DOI : 10.1038/nbt1212.


Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model

P. Liehl; M. Blight; N. Vodovar; F. Boccard; B. Lemaitre

PLoS pathogens. 2006.

DOI : 10.1371/journal.ppat.0020056.


Two proteases defining a melanization cascade in the immune system of Drosophila

H. Tang; Z. Kambris; B. Lemaitre; C. Hashimoto

The Journal of biological chemistry. 2006.

DOI : 10.1074/jbc.M601642200.


The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

F. Leulier; N. Lhocine; B. Lemaitre; P. Meier

Molecular and cellular biology. 2006.

DOI : 10.1128/MCB.00548-06.


Erwinia carotovora Evf antagonizes the elimination of bacteria in the gut of Drosophila larvae

C. Acosta Muniz; D. Jaillard; B. Lemaitre; F. Boccard

Cellular microbiology. 2006.

DOI : 10.1111/j.1462-5822.2006.00771.x.



Structure and metabolism of peptidoglycan and molecular requirements allowing its detection by the Drosophila innate immune system

D. Mengin-Lecreulx; B. Lemaitre

Journal of endotoxin research. 2005.

DOI : 10.1179/096805105X35233.


Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species

N. Vodovar; M. Vinals; P. Liehl; A. Basset; J. Degrouard et al.

Proceedings of the National Academy of Sciences of the United States of America. 2005.

DOI : 10.1073/pnas.0502240102.


Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

A. Kleino; S. Valanne; J. Ulvila; J. Kallio; H. Myllymäki et al.

The EMBO journal. 2005.

DOI : 10.1038/sj.emboj.7600807.



Drosophila: a polyvalent model to decipher host-pathogen interactions

N. Vodovar; C. Acosta; B. Lemaitre; F. Boccard

Trends in microbiology. 2004.

DOI : 10.1016/j.tim.2004.03.007.


In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults

S. Pili-Floury; F. Leulier; K. Takahashi; K. Saigo; E. Samain et al.

The Journal of biological chemistry. 2004.

DOI : 10.1074/jbc.M313324200.


The road to Toll

B. Lemaitre

Nature reviews. Immunology. 2004.

DOI : 10.1038/nri1390.


A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity

C.-I. Chang; S. Pili-Floury; M. Hervé; C. Parquet; Y. Chelliah et al.

PLoS biology. 2004.

DOI : 10.1371/journal.pbio.0020277.


Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

C. R. Stenbak; J.-H. Ryu; F. Leulier; S. Pili-Floury; C. Parquet et al.

Journal of immunology. 2004.

DOI : 10.4049/jimmunol.173.12.7339.



A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster

A. Basset; P. Tzou; B. Lemaitre; F. Boccard

EMBO reports. 2003.

DOI : 10.1038/sj.embor.embor730.


The Drosophila immune system detects bacteria through specific peptidoglycan recognition

F. Leulier; C. Parquet; S. Pili-Floury; J.-H. Ryu; M. Caroff et al.

Nature immunology. 2003.

DOI : 10.1038/ni922.


Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses

F. Leulier; C. Marchal; I. Miletich; B. Limbourg-Bouchon; R. Benarous et al.

EMBO reports. 2003.

DOI : 10.1038/sj.embor.embor936.


Sensing microbes by diverse hosts. Workshop on pattern recognition proteins and receptors.

S. E. Girardin; D. J. Philpott; B. Lemaitre

EMBO reports. 2003.

DOI : 10.1038/sj.embor.embor940.



27 Methods for studying infection and immunity in Drosophila

P. Tzou; M. Meister; B. Lemaitre

Methods in Microbiology. 2002.

DOI : 10.1016/s0580-9517(02)31028-6.


Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants

P. Tzou; J.-M. Reichhart; B. Lemaitre

Proceedings of the National Academy of Sciences of the United States of America. 2002.

DOI : 10.1073/pnas.042411999.


Immunology. Pathogen surveillance--the flies have it.

R. S. Khush; F. Leulier; B. Lemaitre

Science (New York, N.Y.). 2002.

DOI : 10.1126/science.1071208.


The mosquito genome: the post-genomic era opens

E. De Gregorio; B. Lemaitre

Nature. 2002.

DOI : 10.1038/419496a.


A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade

R. S. Khush; W. D. Cornwell; J. N. Uram; B. Lemaitre

Current biology : CB. 2002.

DOI : 10.1016/s0960-9822(02)01214-9.


How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions

P. Tzou; E. De Gregorio; B. Lemaitre

Current opinion in microbiology. 2002.

DOI : 10.1016/S1369-5274(02)00294-1.


The Toll and Imd pathways are the major regulators of the immune response in Drosophila

E. De Gregorio; P. T. Spellman; P. Tzou; G. M. Rubin; B. Lemaitre

The EMBO journal. 2002.

DOI : 10.1093/emboj/21.11.2568.


Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults

F. Leulier; S. Vidal; K. Saigo; R. Ueda; B. Lemaitre

Current biology : CB. 2002.

DOI : 10.1016/S0960-9822(02)00873-4.


An immune-responsive Serpin regulates the melanization cascade in Drosophila

E. De Gregorio; S.-J. Han; W.-J. Lee; M.-J. Baek; T. Osaki et al.

Developmental cell. 2002.

DOI : 10.1016/S1534-5807(02)00267-8.



Drosophila immunity: two paths to NF-kappaB

R. S. Khush; F. Leulier; B. Lemaitre

Trends in immunology. 2001.

DOI : 10.1016/S1471-4906(01)01887-7.


Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

S. Vidal; R. S. Khush; F. Leulier; P. Tzou; M. Nakamura et al.

Genes & development. 2001.

DOI : 10.1101/gad.203301.


Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

E. De Gregorio; P. T. Spellman; G. M. Rubin; B. Lemaitre

Proceedings of the National Academy of Sciences of the United States of America. 2001.

DOI : 10.1073/pnas.221458698.



Le génome de la mouche du vinaigre

B. Lemaitre

Médecine/Sciences. 2000.

DOI : 10.4267/10608/1713.


Genes that fight infection: what the Drosophila genome says about animal immunity

R. S. Khush; B. Lemaitre

Trends in genetics : TIG. 2000.

DOI : 10.1016/S0168-9525(00)02095-3.


The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response

A. Basset; R. S. Khush; A. Braun; L. Gardan; F. Boccard et al.

Proceedings of the National Academy of Sciences of the United States of America. 2000.

DOI : 10.1073/pnas.97.7.3376.


Comparative genomics of the eukaryotes

G. M. Rubin; M. D. Yandell; J. R. Wortman; G. L. Gabor Miklos; C. R. Nelson et al.

Science (New York, N.Y.). 2000.

DOI : 10.1126/science.287.5461.2204.


Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells

Y. S. Kim; J. H. Ryu; S. J. Han; K. H. Choi; K. B. Nam et al.

The Journal of biological chemistry. 2000.

DOI : 10.1074/jbc.M003934200.


Stop press: genes that fight infections: what the drosophila genome says about animal immunity

R. Khush; B. Lemaitre

Trends in genetics : TIG. 2000.

DOI : 10.1016/S0168-9525(00)02133-8.


Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia

P. Tzou; S. Ohresser; D. Ferrandon; M. Capovilla; J. M. Reichhart et al.

Immunity. 2000.

DOI : 10.1016/S1074-7613(00)00072-8.


The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

F. Leulier; A. Rodriguez; R. S. Khush; J. M. Abrams; B. Lemaitre

EMBO reports. 2000.

DOI : 10.1093/embo-reports/kvd073.



La drosophile : un modèle pour l'étude de la réponse immunitaire innée

B. Lemaitre

Médecine/Sciences. 1999.

DOI : 10.4267/10608/1191.


A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF

P. Manfruelli; J. M. Reichhart; R. Steward; J. A. Hoffmann; B. Lemaitre

The EMBO journal. 1999.

DOI : 10.1093/emboj/18.12.3380.



Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

B. Lemaitre; J. M. Reichhart; J. A. Hoffmann

Proceedings of the National Academy of Sciences of the United States of America. 1998.

DOI : 10.1073/pnas.94.26.14614.


A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

D. Ferrandon; A. C. Jung; M. Criqui; B. Lemaitre; S. Uttenweiler-Joseph et al.

The EMBO journal. 1998.

DOI : 10.1093/emboj/17.5.1217.


In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila

E. Nicolas; J. M. Reichhart; J. A. Hoffmann; B. Lemaitre

The Journal of biological chemistry. 1998.

DOI : 10.1074/jbc.273.17.10463.


Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin

E. A. Levashina; S. Ohresser; B. Lemaitre; J. L. Imler

Journal of molecular biology. 1998.

DOI : 10.1006/jmbi.1998.1705.



Antimicrobial peptide defense in Drosophila

M. Meister; B. Lemaitre; J. A. Hoffmann

BioEssays : news and reviews in molecular, cellular and developmental biology. 1997.

DOI : 10.1002/bies.950191112.


Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap

A. Braun; B. Lemaitre; R. Lanot; D. Zachary; M. Meister

Genetics. 1997.



Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila

E. Nicolas; A. J. Nappi; B. Lemaitre

Developmental and comparative immunology. 1996.

DOI : 10.1016/0145-305X(96)00017-1.


The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

B. Lemaitre; E. Nicolas; L. Michaut; J. M. Reichhart; J. A. Hoffmann

Cell. 1996.

DOI : 10.1016/S0092-8674(00)80172-5.



Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila

B. Lemaitre; M. Meister; S. Govind; P. Georgel; R. Steward et al.

The EMBO journal. 1995.

DOI : 10.1002/j.1460-2075.1995.tb07029.x.


A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

B. Lemaitre; E. Kromer-Metzger; L. Michaut; E. Nicolas; M. Meister et al.

Proceedings of the National Academy of Sciences of the United States of America. 1995.

DOI : 10.1073/pnas.92.21.9465.



Drosophila P element: transposition, regulation and evolution

D. Coen; B. Lemaitre; M. Delattre; H. Quesneville; S. Ronsseray et al.

Genetica. 1994.

DOI : 10.1007/BF01435240.



Maternal repression of the P element promoter in the germline of Drosophila melanogaster: a model for the P cytotype

B. Lemaitre; S. Ronsseray; D. Coen

Genetics. 1993.


Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila

J. M. Reichhart; P. Georgel; M. Meister; B. Lemaitre; C. Kappler et al.

Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie. 1993.


Maternal inheritance of P cytotype in Drosophila melanogaster: a "pre-P cytotype" is strictly extra-chromosomally transmitted

S. Ronsseray; B. Lemaitre; D. Coen

Molecular & general genetics : MGG. 1993.

DOI : 10.1007/BF00280208.


Insect immunity: the diptericin promoter contains multiple functional regulatory sequences homologous to mammalian acute-phase response elements

P. Georgel; M. Meister; C. Kappler; B. Lemaitre; J. M. Reichhart et al.

Biochemical and biophysical research communications. 1993.

DOI : 10.1006/bbrc.1993.2508.



L'element P de drosophila melanogaster : mecanismes controlant la transposition

B. Lemaitre / D. Coen; D. Anxolabemere (Dir.)

Université de Paris 6, 1992.



P regulatory products repress in vivo the P promoter activity in P-lacZ fusion genes

B. Lemaitre; D. Coen

Proceedings of the National Academy of Sciences of the United States of America. 1991.

DOI : 10.1073/pnas.88.10.4419.